Attention has been drawn to the sensitivity of Proteus, and the strains of Proteus mirabilis have been proven more sensitive than the other strains. Gram staining can help guide antibiotic therapy. Strains requiring higher concentrations have been correctly considered as extra resistant. Cloudy urine often is a result of precipitated phosphate crystals in alkaline urine, but pyuria also can be the cause. The minimal inhibitory concentrations for those strains were mostly 10μg.-20μg. There are a few reports in the literature of septicemias caused by Gram-negative resistant bacteria (as Proteus) that were cured by huge doses of penicillin. If we modify our definition of sensitivity and go to higher concentrations than those usually attained in the body after the clinical dosage forms of penicillin, we may encounter a few strains that are inhibited by moderate concentrations of the antibiotic. antibiotic therapy is usually required for symptomatic UTI, unnecessary antibiotic treatment for. Of the Gram-negative flora, those really sensitive to penicillin are the Neisseriae, which behave chemotherapeutically the same way as the Gram-positive cocci. rising quinolone resistance in Gram negative bacteria.
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